The interactive effects of dietary saturated fat and apolipoprotein-E genotype on peripheral metabolism of lipoprotein-amyloid and neurovascular integrity.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/2001090

Funding Status
Status not available

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Funded Activity Summary

This project is based on a remarkable discovery which suggests that in some individuals, Alzheimer's disease may be a consequence of corruption of microscopic blood vessels that supply brain, damaged as a consequence of exaggerated exposure in blood to a protein produced principally in liver. The project will explore this pathway further in subjects at heightened risk of Alzheimer's disease and in humanised animal models. The findings may provide new opportunities for prevention and treatment.

Funded Activity Details

Start Date: 01-01-2020

End Date: End date not available

Funding Scheme: Ideas Grants

Funding Amount: $637,536.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

apolipoprotein e | blood-brain barrier | lipoprotein metabolism | neurodegeneration

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