Intergenerational impacts of paternal immune activation on brain function and dysfunction

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/2000661

Funding Status
Status not available

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Funded Activity Summary

We recently discovered that infection of male mice with a parasite (Toxoplasma gondii) before conception can change the epigenetic information in the sperm and alter behaviour of the offspring. This is the first evidence that pathogenic infection in males can affect the next generation. We will investigate how infection with other major pathogens, including bacteria and the virus causing COVID-19, may affect sperm epigenetics and offspring health, including their brain function and dysfunction.

Funded Activity Details

Start Date: 01-01-2020

End Date: End date not available

Funding Scheme: Ideas Grants

Funding Amount: $997,690.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

cognitive disorders | epigenetics | immune-mediated inflammation | psychiatric disorders

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