Microarray analysis of Vegf-b knockout mice.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/199604

Funding Status
Closed

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Funded Activity Summary

The properties of Vegf-B suggest that it may play a role in new blood vessel formation (angiogenesis) especially during the development of the heart. Mice with the Vegf-b gene deleted are viable and fertile but display cardiac dysfunction as the animals age and in experimental conditions of ischemia. Comparison of total gene expression in the hearts of mice lacking Vegf-B with those of normal mice will identify genes involved in blood vessel formation during cardiac development and maintenance. The genes identified will be targets for designing potential new drugs and therapies for cardiovascular disease.

Funded Activity Details

Start Date: 01-01-2002

End Date: 01-01-2004

Funding Scheme: NHMRC Project Grants

Funding Amount: $226,320.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Genetics Not Elsewhere Classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

VEGF (Vascular endothelial growth factor) | angiogenesis | cardiac ischemia | differential gene expression | gene discovery | gene knock-out | microarray | microarrays

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