Regulation of regeneration of Dopaminergic neurones in the substantia nigra

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/194411

Funding Status
Closed

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Funded Activity Summary

Parkinson's Disease (PD) results from the progressive loss of brain cells in the part of the brain called substantia nigra. These brain cells contain a chemical called Dopamine (DA). The symptoms of Parkinson's disease arise when about 80% these DA neurones are lost suggesting that some form of compensation must occur up to this point. In previous studies we have demonstrated that one mechanism for this compensation is through sprouting or branching of the remaining neurones. We have preliminary evidence about the way this is sprouting and regeneration is controlled. The aim of this grant is to explore in detail the mechanisms whereby sprouting is induced and regulated. The significance of this study is that it may provide insights into the way in which regulation of regeneration of the nervous system is controlled. It has specific applications to therapies for Parkinson's disease.

Funded Activity Details

Start Date: 01-01-2002

End Date: 01-01-2002

Funding Scheme: NHMRC Project Grants

Funding Amount: $115,880.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical infection agents (incl. prions)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Movement disorders | Parkinson's disease | axon regeneration | basal ganglia | dopamine | nervous system disorders | neural plasticity | neurogenesis | neurological disease

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