A study addressing motor, cognitive and attentional deficits in presymptomatic gene carriers for Huntington's disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/194219

Funding Status
Closed

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Funded Activity Summary

Since the discovery of the Huntington's disease (HD) gene mutation there has been much controversy in the literature relating to whether there are any preclinical deficits in individuals who are gene positive for HD but who have not yet been clinically diagnosed with the disease. Our aim is to examine, over a three year period, the cognitive, attentional and motor performance of presymptomatic gene-positive, and negative, individuals on a wide variety of computerized experimental procedures, which we have previously shown to be sensitive to deficits in individuals who have already been diagnosed with HD. If progressive behavioural changes in gene-positive individuals can be reliably documented to occur before the clinical symptoms of HD are evident, this would be of profound significance as it would allow a set of criteria to be established to assist in early detection of clinical onset of symptoms, and possibly permit use of newly-emerging therapies.

Funded Activity Details

Start Date: 01-01-2002

End Date: 01-01-2004

Funding Scheme: NHMRC Project Grants

Funding Amount: $180,330.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Economic history

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

Cognition and Attention Deficits | Experimental Neuropsychology | Gene Positive | Huntington's Disease | Movement Disorders | Preclinical | Presymptomatic Gene Carriers for Huntington's disease

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