Tumor specific variants of the EGFR: Characterization, function and target for immunotherapy.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/191500

Funding Status
Closed

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Funded Activity Summary

Antibodies are a major component of the bodies immune system that bind (i.e. stick) to foreign substances such as viruses. Once bound, these antibodies can activate other parts of the immune system, which help destroy the foreign substance. Analogous to the situation above, a number of institutions are testing antibodies that bind to cancer cells, in order to determine if they are able to destroy these cells. This therapeutic approach requires an antibody that specifically binds to cancer cells but not normal cells. In this proposal, we wish to test a novel antibody that binds to a protein on the cell surface called the EGF receptor. While the EGF receptor is found on the surface on many cells, our antibody recognizes a modified version of the EGF receptor that is found exclusively on cancer cells. Previous EGF receptor antibodies tested in the clinic all recognized the normal EGF receptor and thus proved unsuitable as they bound to cells in the liver causing significant side effects. It is anticipated that the specificity of our novel antibodies will overcome this problem. Eventually this antibody could be used to treat patients with brain, breast, prostate and lung cancer. We will also conduct a number of studies to determine the function of this modified receptor. This work will improve our understanding of those events associated with development of tumors.

Funded Activity Details

Start Date: 01-01-2002

End Date: 01-01-2003

Funding Scheme: NHMRC Project Grants

Funding Amount: $140,880.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Protein Targeting And Signal Transduction

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Antibody Therapy | Breast Cacer | Cancer | Epidermal Growth Factor Receptor | Glioma | Glycosylation | Head and Neck Cancer | Lung Cnacer | Signal Transduction

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