Heritability and biological consequences of human variation in mitotic recombination

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/160049

Funding Status
Closed

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Funded Activity Summary

Cells in our bodies constantly sustain damage to their genetic material (genes) most of which is efficiently repaired. Some is not and accumulated damage to genes in a cell can start a cancer. There are several repair mechanisms that cells possess which have evolved since the earliest life-forms. One repair mechanism homologous recombination repair will, as a minor by-product of its activity, produce an event called mitotic recombination (MR). MR causes a loss of diversity of genes and this can contribute to cancer rather than prevent it. We have shown that the rate at which MR occurs varies very widely in humans. In this project we will devise a simple method for measuring MR, use identical and non identical twins to find if the rate of MR is inherited and finally see whether the rate of MR is associated with risk of cancer, as we expect.

Funded Activity Details

Start Date: 01-01-2001

End Date: 01-01-2002

Funding Scheme: NHMRC Project Grants

Funding Amount: $130,906.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Meiosis And Recombination

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cancer risk | heritability of normal variation in a DNA repair mechanism | homologous recombination repair | human variation in DNA repair | mitotic recombination | population variation in cancer risk | twin studies | understanding LOH - a factor in cancer progression

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