Regulation of the Na-K-Cl co-transporter by the AMP-activated protein kinase

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/156710

Funding Status
Closed

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Funded Activity Summary

The failure of the kidney to excrete enough salt is a major driving force behind high blood pressure, kidney failure and heart disease. At present, it is not known, in any detail, how the kidney is able to recognise that it is not excreting enough salt and how it changes the amount it excretes. This is important if, for example, someone eats a salty meal. Unless the kidney recognises that there is an excess of salt and adjusts itself to excrete it, then salt accumulates leading to high blood pressure, kidney and cardiac problems. In this study, we have identified a new mechanism that the kidney uses to detect salt and to excrete it. This could be a major advance in our understanding of high blood pressure and other common diseases.

Funded Activity Details

Start Date: 01-01-2001

End Date: 01-01-2003

Funding Scheme: NHMRC Project Grants

Funding Amount: $227,036.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Nephrology And Urology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

AMP-activated protein kinase | Na-K-Cl co-transporter | hypertension | kidney failure | nephrology | tubuloglomerular feedback

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