L-amino acid sensing by the extracellular calcium-sensing receptor: molecular, cellular and in vivo studies

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/153966

Funding Status
Closed

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Funded Activity Summary

Recent work by Dr Conigrave and colleagues demonstrates for the first time that protein and calcium metabolism are linked at the molecular level by the widely distributed calcium-sensing receptor. The project will aim to demonstrate the physiological significance of this finding by testing whether L-amino acids, the building blocks of body protein, exert receptor-dependent control over the secretion and blood levels of hormones that regulate body calcium levels. It will further test the hypothesis by determining whether amino acids exert receptor-dependent control over the proliferation of bone forming cells and urinary excretion of calcium.

Funded Activity Details

Start Date: 01-01-2001

End Date: 01-01-2003

Funding Scheme: NHMRC Project Grants

Funding Amount: $362,545.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Nutritional science

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Cellular sensing of L-amino acids | L-amino acids | Primary hyperparathyroidism | Secondary hyperparathyroidism | calcium-sensing receptor | receptor sensitivity

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