TNF receptor 2 and iNOS genes in basis of cardiovascular disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/153781

Funding Status
Closed

Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the .

Funded Activity Summary

Cardiovascular diseases account for almost half of total deaths in Australia and other industrialized countries. Hypertesnion, coronary artery disease and diabetes are major contributing factors to mortality and morbidity. It is well known that each of these have a genetic basis, as well as having environmental influences. A key focus of reseach internationally is discovery of the molecular mechanisms involved. Our recent findings point to a role for the inducible nitric oxide synthase gene (which generates nitric oxide, a potent blood vessel dilator) and tumor necrosis factor receptor 2 gene (whose product sends signals to the former gene) in heart, kidney and blood vessel diseases. We now propose to find the actual gene changes responsible and the molecules and mechanisms involved. By elucidating roles in cardiovascular physiology and pathology the importance of these for cardiovascular function will be ascertained, and may open up new avenues for treatment.

Funded Activity Details

Start Date: 01-01-2001

End Date: 01-01-2003

Funding Scheme: NHMRC Project Grants

Funding Amount: $242,545.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Nutrigenomics and personalised nutrition

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Coronary artery disease | Cytokines | Diabetes | Diabetic nephropathy | Essential hypertension | Metabolic syndrome | Molecular biology | Molecular genetics

Related Links