TEMPERATURE AS MODIFIER OF MAMMALIAN SKELETAL MUSCLE FUNCTION AND OF MUSCLE RESPONSIVENESS TO PHYSIOLOGICAL FACTORS

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/148645

Funding Status
Closed

Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the .

Funded Activity Summary

Contracting muscles are a major source of heat production in the body. Heat produced by contracting muscles can cause muscle damage if muscle temperature increases above 44oC. Also, overheating from external sources can cause an increase in muscle temperature in the upper physiological range of temperature (37-44oC) which can so readily happen to humans and animals caught in blistering sun or in closed cars parked in the sun. However, very little is known about what happens to the ability of the skeletal muscle to contract when the temperature increases in this upper physiological range of temperature. This project seeks to fill in this important gap in our knowledge and increase our understanding about the existence of protective mechanisms in muscle to prevent heat-induced damage to the muscle. Such mechanisms would allow the body to operate very close to the lethal range of temperature and may be mainly responsible for the severe muscle weakness in overheated individuals. Results obtained from the project can have far reaching implications for human physiology in general and muscle and exercise physiology in particular and for developing new strategies in the treatment of collapse from body overheating. The project will also produce new knowledge regarding the mechanism of action of drugs used in the treatment of certain mental disorders but which can trigger, in susceptible individuals, uncontrolled contraction of muscles and overheating.

Funded Activity Details

Start Date: 01-01-2001

End Date: 01-01-2003

Funding Scheme: NHMRC Project Grants

Funding Amount: $256,018.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical biotechnology diagnostics (incl. biosensors)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

actions of neuroleptic drugs on muscle | effects of antipsychotic drugs on muscle contractility | hyperthermia | hyperthermia and temperature induced damage to muscle | mammalian muscle physiology | muscle contraction | neuroleptic malignant syndrome | regulation of muscle contraction | temperature induced muscle damage | wellness

Related Links