Respiratory-control deficits in a model of sleep apnoea during early development: Mechanisms and associations

Funded Activity Summary

A recent study showed that it is possible to induce changes in the respiratory control system of piglets after birth. This new study will examine the mechanism of that change, and develop diagnostic tools that can detect whether similar changes have occurred in babies. The results will help to diagnose the complications of respiratory problems in young babies, and will guide research regarding the potential site of the abnormalities that predispose to SIDS. Piglets have very similar development of the brain and respiratory system to human infants during early development after birth. This study uses piglets to model exposure to factors that occur during infancy, and thus model some of the common respiratory diseases, including risk factors for the sudden infant death syndrome (SIDS). For example, infants may have upper-airway obstruction during sleep, or may get their face trapped in bed clothes so that they breath a mixture of lower oxygen and higher carbon-dioxide than that found in fresh air. We recently found that, during early development of piglets, repeated exposure to these types of gas mixes depressed respiratory responses tested later. Thus, respiratory responses become less vigorous over time, and this finding could explain how the exposures complicate infants' respiratory problems, or increase their risk for SIDS: Less vigorous responses mean the infant does not wake or move, the exposure becomes more severe, and may finally cause death. This study will examine piglets after such repeated exposure to: 1. find out whether heart-rate variability is reduced, in the same way as babies who later died from SIDS 2. develop a new diagnostic tool, to show the site where the abnormality is located 3. determine whether brain chemical alterations could explain the change in breathing 3. find out if exposure to cigarette smoke, known to increase respiratory problems in babies, causes even more severe disturbance of respiratory control in piglets.

Funded Activity Details

Start Date: 01-01-2001

End Date: 01-01-2003

Funding Scheme: NHMRC Project Grants

Funding Amount: $206,717.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical molecular engineering of nucleic acids and proteins

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

apparent life-threatening event | hypercapnic-hypoxia | infantile apnoea | nicotine | obstructive sleep apnoea | repeated hypoxia | respiratory control | sudden infant death syndrome | ventilatory responses

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