Functional analyses of the major merozoite surface protein of malaria parasites

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/145710

Funding Status
Closed

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Funded Activity Summary

In this project we aim to learn about the function of one of the leading malaria vaccine candidates, merozoite surface protein 1 (MSP-1). Although a promising candidate, little is known about the role of this protein in the invasion by parasites of red blood cells or of the likelihood that the parasites will adapt to avoid vaccines based on MSP-1. To address these issues we propose to use the powerful new technology of parasite transfection, that is the ability to insert DNA into parasites to specifically alter its genetic code. We have pioneered this technology and have developed many of the most effective tools for the process. Insight gained from these studies is likely to influence significantly the design and potential uses of MSP-1 as a vaccine to control malaria.

Funded Activity Details

Start Date: 01-01-2001

End Date: 01-01-2001

Funding Scheme: NHMRC Project Grants

Funding Amount: $70,285.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Humoural immunology and immunochemistry

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Plasmodium | falciparum | malaria | merozoite | surface protein | systemic infection | transfection | vaccines

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