Developmental potential of murine keratinocyte stem cells

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/145654

Funding Status
Closed

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Funded Activity Summary

The stem cells of the epidermis or outer lining of the skin are an important group of cells with a role in normal cell replenishment, in wound healing and in skin disorders such as psoriasis and cancer. These primitive cells remain in the skin during the lifetime of an individual and are responsible for the production of mature, functional cells that form a protective barrier against the environment and pathogens. We have recently developed a strategy for the isolation of stem cells of the skin which places us in a unique position to further study these cells and determine possible therapeutic approaches for the future. The aims of this project encompass testing the potency of skin stem cells (i) to reform complex structures such as a mature epidermis, hair follicles and sebaceous glands; and (ii) to give rise to cells from other tissues such as muscle and liver. A final aim of this project is to dissect the complexity of the stem cell compartment further to gain insights into how normal skin growth is regulated.

Funded Activity Details

Start Date: 01-01-2001

End Date: 01-01-2003

Funding Scheme: NHMRC Project Grants

Funding Amount: $212,036.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Food properties (incl. characteristics and health benefits)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

epidermis | gene therapy | keratinocyte stem cells | pluripotentiality | psoriasis | skin biology | skin cancer | tissue regeneration | wound healing

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