Morphological and spectroscopic study of monozygotic twins discordant for epilepsy

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/144103

Funding Status
Closed

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Funded Activity Summary

Understanding the causes of epilepsies is essential for treatment and prevention. In many people with epilepsy the cause is not obvious and is frequently attributed to events at birth or minor head injuries. It is clear that these factors are generally not important. There is increasing evidence that subtle changes in brain structure, reflecting developmental or maturational abnormalities, may be the cause of these epilepsies. Such subtle changes can be detected by novel magnetic resonance imaging strategies. However, due to individual differences of brain morphology, the significance of such subtle changes can be disputed. Monozygotic twins have an increased similarity of their brain morphology. Therefore, analysis of monozygotic twins where only one twin is affected with epilepy, is a powerful way to characterize significant brain abnormalities. This will provide novel information on the causes of epilepsy relevant to the general population.

Funded Activity Details

Start Date: 01-01-2001

End Date: 01-01-2002

Funding Scheme: NHMRC Project Grants

Funding Amount: $139,079.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Neurology And Neuromuscular Diseases

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Epilepsy | Genetics | Neuroimaging | Twin research

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