Functional characterisation of Pendrin: the anion transporter causing Pendred Syndrome

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/143096

Funding Status
Closed

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Funded Activity Summary

Mutations in the human pendrin protein cause progressive hearing loss from an early age in Pendred syndrome. Using techniques of molecular and cellular biology, we intend to test the effects of Pendred-causing mutations on the function of pendrin expressed in frog and cultured mammalian cells. Our approach will enable us to determine how pendrin functions in both the normal and diseased states, which is currently unknown. This will allow us to consider ways of correcting the ion channel defect associated with the Pendred syndrome.

Funded Activity Details

Start Date: 01-01-2001

End Date: 01-01-2003

Funding Scheme: NHMRC Project Grants

Funding Amount: $211,527.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical biotechnology not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Functional characterisation | Membrane physiology | Pendred Syndrome | anion transport | congenital deafness | hearing loss | ion transport defect | molecular biology | mutation analyses | thyroid goitre

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