Genetic dissection of the biogenesis and function of type IV fimbriae of Pseudomonas aeruginosa

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/143054

Funding Status
Closed

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Funded Activity Summary

Pseudomonas aeruginosa is a common bacterium which causes serious life-threatening infections of individuals with cystic fibrosis, AIDS or who have suffered severe burns or are undergoing cancer chemotherapy. This pathogen, and a number of other important infectious bacteria use surface filaments, called fimbriae, like grappling hooks to attach to the cells of the body and to move across host tissues. These fimbriae are produced in response to environmental conditions, and are assembled by a process that is also used in the export of toxins and other pathogenic molecules. This project will characterise genes which specify and control this system, as a means to design better treatments against such bacteria, many of which are resistant to antibiotic treatment.

Funded Activity Details

Start Date: 01-01-2001

End Date: 01-01-2003

Funding Scheme: NHMRC Project Grants

Funding Amount: $407,545.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Allergy

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

Pseudomonas aeruginosa | burns patients | cystic fibrosis | fimbriae | host colonisation | immunocompromised patients | infection | nosocomial infections

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