Regulation of signal transduction by Cbl: investigation of effects on the cytoskeleton, cell adhesion and cell motility

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/139021

Funding Status
Closed

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Funded Activity Summary

Changes in cell adhesion and motility have been implicated in a wide range of human pathologies (e.g. immune, reproductive, mental, and cancerous disorders) . Cell adhesion and motility are tightly regulated by a group of proteins known as Rho-GTPases. Novel pharmacological agents that target signalling by Rho-GTPases have been demonstrated to profoundly affect tumour metastasis, as well as central nervous system regeneration following injury. Further exploitation of Rho-GTPase signal modulation, by detailed studies of the molecular mechanisms involved, could lead to significant advances in medical sciences. In particular, treatment of cancer and spinal injuries are likely to benefit from further development of Rho-signalling research.

Funded Activity Details

Start Date: 01-01-2001

End Date: 01-01-2003

Funding Scheme: NHMRC Project Grants

Funding Amount: $256,527.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Protein Targeting And Signal Transduction

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Actin cytoskeleton | Anti-cancer drugs | Cell motility and adhesion | Nerve regeneration | Rac and Rho GTPase signalling | Tumour metastasis | Tyrosine kinases | Wound healing

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