Studies on the effects of RSV infection during infancy on aeroallergen-specific T-cell immunity and lung function

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/139020

Funding Status
Closed

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Funded Activity Summary

Many infants who develop transient severe wheezing in association with respiratory infections, go on to develop asthma which can persist throughout childhood and some times into adult life. It is not known whether the respiratory infections are a direct cause of later asthma, or whether they simply function as flag which identifies children who have a genetic predisposition to wheeze e.g. because they have abnormally narrow airways. This project will compare the effects of respiratory infection in infants with the RSV virus, who contract the disease at different ages, and who have varying levels of genetic risk for respiratory allergies. In particular, it will examine the possibility that in certain cases, infection of genetically susceptible individuals during early infancy will boost the development of allergies to airborne environmental allergens (such as house dust mite) which are known to trigger asthma attacks in older children and adults.

Funded Activity Details

Start Date: 01-01-2001

End Date: 01-01-2001

Funding Scheme: NHMRC Project Grants

Funding Amount: $130,475.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Anaesthesiology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Allergy | Asthma | Asthma aetiology | Infancy | RSV infection in infants | Respiratory allergy | Respiratory syncitial virus infection | Th1/Th2 regulation | Viral bronchiolitis

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