Cell division and the regulation of immunoglobulin switch recombination at the molecular level

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/137860

Funding Status
Closed

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Funded Activity Summary

The B lymphocyte is an important cell in the immune response as it generates protective antibody against invading pathogens. The effectiveness of an antibody response partly depends on the type of antibody made (there are eight different types). This attribute alters as the immune response progresses in a poorly understood and highly complex way. However, our recent studies have revealed a simple underlying order that can be dissected using new methods. The key to the underlying simplicity is a cell division clock used to relate and promote cell changes. Here we intend to apply this new concept and the new methods to dissecting the molecular events associated with linking division to the changing properties of antibody selection. Our aim is to accurately model the process of changing antibody types at both the molecular and whole tissue levels. These studies will give us new insights into how the immune response may be directed to make the most appropriate (effective) response during infection and vaccination.

Funded Activity Details

Start Date: 01-01-2001

End Date: 01-01-2003

Funding Scheme: NHMRC Project Grants

Funding Amount: $392,545.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Clinical microbiology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Allergy | Asthma | Cell division | DNA methylation | DNA repair | Immunodeficiencies | Isotype switching | Lymphocyte differentiation | Lymphoma

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