Investigation of a virulence locus on chromosome 9 of Plasmodium falciparum utilising improved transfection technology

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/137211

Funding Status
Closed

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Funded Activity Summary

Worldwide, there are approximately 500 million cases of malaria per year with over 1 million deaths, predominately in children under 5 years of age in Africa. We have identified a region of the malaria parasites' genome that we believe is responsible for two aspects of the parasites life cycle. Firstly, there is a gene responsible for the development of the sexual stage of the parasite that allows transmission from humans to mosquitoes and secondly there are two other genes that allow the parasite to evade the human hosts immune system. We intend to investigate these genes using newly developed genetic engineering tools with the ultimate aim of finding agents or vaccines that can block their action, thus preventing either transmission of the parasite or the severe effects of infection.

Funded Activity Details

Start Date: 01-01-2001

End Date: 01-01-2003

Funding Scheme: NHMRC Project Grants

Funding Amount: $211,527.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Humoural immunology and immunochemistry

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Hypoxanthine xanthine guanine phosphoribosytl transferase | Malaria therapy | Malaria transmission | Plasmodium falciparum | Severe Malaria | Transfection vectors | gametocytogenesis and cytoadherence

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