The cellular and molecular basis to the paradox of positive versus negative T cell selection

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/124492

Funding Status
Closed

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Funded Activity Summary

The protection against disease requires the generation of white blood cells called T lymphocytes that are produced in the thymus. Each T cell has a specific surface receptor, generated by random gene switching, that can react against foreign pathogens. Since there is a very high conservation of molecules used in all organisms, some of these receptors could by chance also react against normal cells in the host. Eliminating all such self-reactive cells would mean, however, the repertoire remaining for eliminating infection would be too low and immunodeficiency develops. This project investigates the mechanisms controlling the balance between defence infection and the need to prevent immune-based self destruction termed autoimmunity.

Funded Activity Details

Start Date: 01-01-2000

End Date: 01-01-2002

Funding Scheme: NHMRC Project Grants

Funding Amount: $278,090.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Clinical chemistry (incl. diagnostics)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Autoimmunity | Immunodeficiencies | Inflammatory bowel disease | Mechanisms of positive and negative thymus selection | Possible thymic selection abnormalities in autoimmunity | Role of thymic medulla in maturation and tolerance

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