The role of proteinase inhibitor 9 in cytotoxic lymphocyte function

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/124411

Funding Status
Closed

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Funded Activity Summary

Cytotoxic lymphocytes eliminate virus-infected or cancerous cells from the body. This is achieved by the release of powerful cytotoxins that kill the abnormal cell. Unless carefully targeted these cytotoxins can damage surrounding normal tissue or the cytotoxic lymphocyte itself, and lead to autoimmune disease. One of the most important cytotoxins is a protease called granzyme B. We have discovered a natural inhibitor of granzyme B that is present in cytotoxic cells and testis. Our studies are aimed at understanding the role of the inhibitor in human immune and reproductive function. We will also design and evaluate synthetic compounds based on the natural inhibitor that will enable us to easily measure granzyme B levels and control its activity.

Funded Activity Details

Start Date: 01-01-2000

End Date: 01-01-2004

Funding Scheme: NHMRC Project Grants

Funding Amount: $820,136.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Clinical chemistry (incl. diagnostics)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Autoimmunity | Cytotoxic lymphocyte | Granzyme B | Infection | Proteinase inhibitor 9 (PI-9) | Serine proteinase inhibitor (serpin) | Transplant rejection

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