PURINERGIC TRANSMISSION AND CENTRAL AUTONOMIC REGULATION

Funding Activity

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Funded Activity Summary

The brain regulates bodily functions in a complex manner. One such example is the regulation of blood pressure and heart rate. This is achieved by an interconnected network of brain nuclei that sense information from the major blood vessels and integrate appropriate responses to maintain the status quo. Chemicals called neurotransmitters convey the nervous messages, and one such example is purines, which include ATP and adenosine. Both ATP and adenosine can act in a number of brain regions to modulate blood pressure and heart rate. This project is designed to characterise the mechanism by which purines act within specific brain nuclei to regulate the cardiovascular system. Considering the large economic burden on the healthcare system caused by cardiovascular disease, this research is vital to increase our understanding of how diseases such as hypertension may be caused, and therefore provide improved therapeutic strategies.

Funded Activity Details

Start Date: 01-01-2000

End Date: 01-01-2002

Funding Scheme: NHMRC Project Grants

Funding Amount: $157,848.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical infection agents (incl. prions)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

ATP | BLOOD PRESSURE | BRAIN STEM | CARDIOVASCULAR DISEASE | HYPERTENSION | NITRIC OXIDE | STRESS