Circular RNAs as genome destabilisers in human disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1198014

Funding Status
Active

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Funded Activity Summary

Mutation of genes are hallmarks of both cancer and neurological disorders. My research group has identified roles for circular RNAs in both these processes. Now, we must close the loop by investigating the mechanism of these processes. This will inform not only why these genes are commonly mutated, but by exploiting the highly stable circular RNAs they may provide early prognostic/diagnostic biomarkers and even represent novel therapeutic targets for cancer and Huntington’s disease.

Funded Activity Details

Start Date: 05-12-2019

End Date: 01-01-2017

Funding Scheme: Investigator Grants

Funding Amount: $2,163,220.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

alternative splicing | chromatin structure | mutation | oncology

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