Counteracting age-associated neurodegenerative diseases using chaperone-based amyloid disaggregases

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1197021

Funding Status
Status not available

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Funded Activity Summary

In neurodegenerative diseases such as Alzheimer’s disease, proteins form clumps through changes in structure due to mutations or proteotoxic chemical insults. The formation of these toxic clumps causes brain cells to die prematurely triggering symptoms such as dementia. I have identified a molecular machine in human cells that efficiently clears these clumps. We are now developing strategies to activate this machine to repair damaged brain cells to slow/reserve neurodegenerative diseases.

Funded Activity Details

Start Date: 01-01-2020

End Date: End date not available

Funding Scheme: Investigator Grants

Funding Amount: $645,205.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

heat shock proteins | molecular chaperones | neurodegeneration | protein folding

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