Targeting epigenetic mechanisms of immune evasion in cancer

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1196598

Funding Status
Status not available

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Funded Activity Summary

Proteins called MHC class I and II on the surface of cancer cells act as sensors that allow the immune system to recognise cancer cells as abnormal and destroy them. However, cancer cells have developed ways to hide from the immune system by silencing MHC class I and II. This project aims to identify ways to overcome this silencing and restore MHC class I and II to the surface of the cancer cells, allowing them to be treated with therapies that activate immune cells to eradicate the tumour.

Funded Activity Details

Start Date: 01-01-2020

End Date: End date not available

Funding Scheme: Investigator Grants

Funding Amount: $1,425,280.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cancer biology | cancer immunology | epigenetics | immune evasion

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