Characterization and targeting of precursor exhausted T cells (TPEX) for the treatment of chronic infection and cancer

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1194779

Funding Status
Status not available

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Funded Activity Summary

The recent discovery of precursor exhausted CD8 T cells (TPEX) has not only allowed us to conceptualize our understanding of how chronic T cell responses are maintained over long periods of time, but also resulted in a new understanding of the mechanisms underpinning checkpoint inhibition. I will undertake critical characterization of these TPEX in chronic viral infections with the goal to reveal phenotypic and functional properties, which will serve as potential novel targets for immunotherapy.

Funded Activity Details

Start Date: 01-01-2020

End Date: End date not available

Funding Scheme: Investigator Grants

Funding Amount: $606,009.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

cancer immunotherapy | chronic infection | t cell immunity | t cell immunotherapy

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