Precision epigenetics: targeting the epigenome to treat disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1194345

Funding Status
Active

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Funded Activity Summary

Epigenetic marks are changes made to the DNA that allow genes to be switched off in some cells and switched on in others. These marks are critical to normal development and often go wrong in disease. We aim to find genes that add epigenetic marks to the DNA and understand how they co-operate at the molecular level to switch genes off. Our focus is on one such gene, SMCHD1. We are developing new drugs against SMCHD1 to treat incurable neurodevelopmental disorder PWS and muscular dystrophy FSHD.

Funded Activity Details

Start Date: 05-12-2019

End Date: End date not available

Funding Scheme: Investigator Grants

Funding Amount: $1,940,576.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

epigenetics | genomics | mouse models | neurodevelopmental disorders

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