REGULATION AND NOVEL FUNCTIONS OF INDOLEAMINE 2,3-DIOXYGENASE

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/119230

Funding Status
Closed

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Funded Activity Summary

We are studying a protein important in the host's response to infections. The expression of this protein which degrades the least abundant of all essential amino acids, is increased dramatically in inflammatory disorders, and plays a role in the control of cell growth. The protein and products produced along the metabolic pathway it induces have many additional interesting properties, similar to those of another pathway. We propose that these two pathways are functionally related and how the protein of interest is regulated. We will test this directly using purified proteins, isolated cells, and animal studies and employing sophisticated techniques ranging from physical chemistry to molecular biology. We will also examine possible new functions of our protein of interest. These studies will allow us to find ways to regulate the protein and this may be relevant to diseases such as infections and the hardening of arteries.

Funded Activity Details

Start Date: 01-01-2000

End Date: 01-01-2002

Funding Scheme: NHMRC Project Grants

Funding Amount: $268,403.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Oral and maxillofacial surgery

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Atherosclerosis | Indoleamine 2,3-dioxygenase | Infection | Inflammation | Macrophage | Neurological disorders | Raman resonance spectroscopy | Redox regulation

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