Hormonal modulation of prostatic growth and contractility

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/118611

Funding Status
Closed

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Funded Activity Summary

With increasing age human males are likely to develop benign prostatic hyperplasia (BPH), a disorder characterized by urethral obstruction due to an increase in size of the prostate gland. Drug treatments of this condition are not entirely satisfactory and the current project is to examine the mechanisms by which the prostate grows and occludes the urethra. We will use human prostate cells grown in artificial conditions to determine which hormones alter the types of cells and especially examine those cells which can contract as these may be of critical importance in the urethral obstruction. We hypothesize that an enzyme called protein kinase C may be implicitly involved in both cell growth and contractile function and we will examine the role of protein kinase C with a view ultimately to develop drugs which may interfere with this process and therefore aid in non-surgical treatment of the condition.

Funded Activity Details

Start Date: 01-01-2000

End Date: 01-01-2002

Funding Scheme: NHMRC Project Grants

Funding Amount: $324,237.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical biochemistry - carbohydrates

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

aging | androgens | benign prostatic hyperplasia | bladder outlet obstruction | protein kinase C | smooth muscle cell contractility | stromal cell proliferation

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