Targeting the gonadotropin-releasing signal transduction cascade novel approaches to regulating reproduction and obesity

Funded Activity Summary

We know that nutrition and reproduction are closely linked e.g. undernutrition leads to infertility, menopause to weight gain, but we do not know precisely the mechanisms whereby these events occur. The brain hormone gonadotropin-releasing hormone (GnRH), which stimulates the reproductive pathways and a recently discovered family of hormones (orexins) which stimulate feeding both act through the same type of recognition site i.e. G-protein coupled receptors (GPCRs) which are distributed in close proximity within the brain. Identifying how these two pathways interact has enormous potential for the treatment of disorders of weight and-or reproduction since the GPCR structure and the route by which it signals lends itself to therapeutic intervention.

Funded Activity Details

Start Date: 01-01-2000

End Date: 01-01-2002

Funding Scheme: NHMRC Project Grants

Funding Amount: $438,625.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Other biomedical and clinical sciences not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

G-protein coupled receptors | GnRH receptors, orexin receptors | anorexia nervosa, feeding disorders | diabetes | fertility and obesity | hypothalamic control of gonadotropin release | obesity, postmenopausal weight gain | reproductive dysfunction and fertility control | signalling and trafficking pathways targeting reproduction | steroid-dependent cancers (breast and prostate)

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