Cellular and Molecular Events During Antigen Dependent B cell Differentiation

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/115090

Funding Status
Closed

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Funded Activity Summary

The immune system is essential for protecting us against invasion from without by viruses and bacteria and invasion from within by cancer cells. Among the white blood cells making up this system are those responsible for producing antibodies. To ensure that all possible infections and tumours can be recognised, the body needs to manufacture a very large number of these cells on a continuous basis. The aim of this project is to work out the mechanism responsible for controlling their production and function using a novel experimental system. By pinpointing the different stages involved in antibody production in the normal host we should be in a better position to make longer lasting vaccines in the future and to understand what goes wrong with these white cells in disease. In particular, the results should shed light on the chronic form of leukaemia called myeloma and some of the autoimmune disorders like the rheumatic diseases which occur when the antibodies being produced attack our own tissues.

Funded Activity Details

Start Date: 01-01-2000

End Date: 01-01-2001

Funding Scheme: NHMRC Project Grants

Funding Amount: $283,329.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Clinical chemistry (incl. diagnostics)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

B lymphocyte | activation | allergy | autoimmunity | immunoregulation | self tolerance | tolerance | transgenic mice | vaccines

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