Cellular and Molecular mechanisms of transcutaneous immunisation

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/115070

Funding Status
Closed

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Funded Activity Summary

Vaccines are among the most effective medical interventions. The recent discovery that cholera toxin, when applied to the normal skin of humans and laboratory animals, stimulates powerful and protective immune responses to itself, and to other proteins has opened up the possibility of needle-free vaccines in the form of skin patches. How CT brings about this effect is currently unknown. We have discovered that the immune stimulating effect of CT depends upon the production of an immune protein (cytokine) called tumour necrosis factor (TNF). TNF is known to activate specialised immune cells within the skin (Langerhan's Cells ) and we hypothesise that the interaction beween CT and LC via TNF is the pathway to the potent immune response. In this project we propose to investigate the cells and molecules involved in the immune effects of CT in the skin with a view to the development of new skin based vaccine strategies.

Funded Activity Details

Start Date: 01-01-2000

End Date: 01-01-2002

Funding Scheme: NHMRC Development Grants

Funding Amount: $190,490.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Clinical sciences not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

AUOTIMMUNITY | CYTOKINES | IMMUNE DEVIATION | INFECTIOUS DISEASE | LANGERHAN'S CELLS | PAEDIATRICS | SKIN DISEASES | SKIN IMMUNITY | VACCINATION

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