Autoimmunity in double transgenic models of self tolerance

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/115052

Funding Status
Closed

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Funded Activity Summary

The immune system protects the body against infection by means of a population of circulating white blood cells called lymphocytes. Each lymphocyte has on its surface its own particular receptor which recognises only one out of the universe of possible substances. Receptors are generated in a semi-random way, using a combination of elements encoded by the genes, and it is possible to generate receptors that react with the body itself, rather than with invading organisms. If the cells bearing these self-reactive receptors become activated, an autoimmune disease ensues. We are using animal models to study how the body deals with self-reactive cells. We will attempt to activate these cells and thus cause autoimmune disease. The experimental manoeuvres that successfully cause autoimmunity in normal animals will provide clues as to the processes that can cause autoimmune disease.

Funded Activity Details

Start Date: 01-01-2000

End Date: 01-01-2002

Funding Scheme: NHMRC Project Grants

Funding Amount: $157,660.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Emergency medicine

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Autoimmune disease | Autoimmunity | Diabetes | Immunodeficiency | Self tolerance | T cell receptor | Transgenic mice

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