Transcription factor binding Determinates

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1148380

Funding Status
Closed

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Funded Activity Summary

Transcription factors (TFs) read cis-regulatory information encoded in the genome. However, they must compete with structural chromatin proteins such as nucleosomes for access to DNA motifs. It is unclear what features discriminate used from unused binding sites with similar motifs, in vivo. To provide insight and general principles of TF biology, I will express variants of a model TF in mammalian cells and test the contribution that specific molecular properties have on genomic binding.

Funded Activity Details

Start Date: 01-01-2019

End Date: 01-01-2022

Funding Scheme: Early Career Fellowships

Funding Amount: $417,193.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Epigenetics (incl. Genome Methylation and Epigenomics)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

chromatin | chromatin structure | embryonic stem cells | gene regulation | transcription factor

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