Targeting neuroserpin-plasmin interactions to protect the retina in glaucoma

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1147404

Funding Status
Closed

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Funded Activity Summary

Glaucoma causes blindness and despite our best treatment many patients continue to progress. A new approach is needed to protect the cells that die in the retina. We have established that a common protease – plasmin – is involved in the process, and a protein that normally regulates it – neuroserpin – is downregulated in the disease. We aim to modify neuroserpin using an ocular gene therapy approach and show it could be used as a novel therapy in glaucoma.

Funded Activity Details

Start Date: 01-01-2018

End Date: 01-01-2020

Funding Scheme: Project Grants

Funding Amount: $648,965.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Vision Science

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

gene therapy | glaucoma | mouse models | neurodegeneration | serpin

Related Links