Skeletal Disease in a Dish: Using novel in vitro disease models produced from patient induced pluripotent stem cells to reveal pathogenic mechanisms and explore treatments for genetic skeletal disorders

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1146952

Funding Status
Closed

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Funded Activity Summary

Inherited skeletal disorders are a significant disease burden. Many gene mutations have been defined but we only have limited understanding about how they cause the disease. We will use patient skin cells and a new in vitro cell reprogramming technology to induce them to form cartilage and bone cells to produce mutation-specific “disease in a dish” models. These models will allow us to answer questions about how specific mutations cause disease and test novel drug therapies

Funded Activity Details

Start Date: 01-01-2018

End Date: 01-01-2020

Funding Scheme: Project Grants

Funding Amount: $808,551.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Interactions (incl. Adhesion, Matrix, Cell Wall)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

chondrocytes | collagen | osteogenesis imperfecta | protein folding | stress response