Defining the role of a novel transcriptional enhancer element in regulation of Prox1 expression and endothelial cell identity.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1146706

Funding Status
Closed

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Funded Activity Summary

The precise spatial and temporal control of gene expression is regulated by non-coding regions of the genome termed enhancers. Enhancers are crucial to program cell identity and have established roles in development and disease. We have identified a novel enhancer that we hypothesise controls the identity of valve endothelial cells by regulating expression of a master programmer of lymphatic endothelial cell identity, PROX1. Here we will investigate the role of this enhancer during development.

Funded Activity Details

Start Date: 01-01-2018

End Date: 01-01-2020

Funding Scheme: Project Grants

Funding Amount: $706,909.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Developmental Genetics (incl. Sex Determination)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

developmental genetics | enhancer | haematopoiesis | lymphangiogenesis | transcriptional regulation

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