The Hippo/Yap pathway reprograms glucose metabolism to fuel tissue growth.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1146558

Funding Status
Closed

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Funded Activity Summary

Liver disease is a common cause of sickness and death in Australia. While factors critical to liver function are known, the cellular networks responsible for causing liver cancer are largely undefined. Our studies will use zebrafish as a model to study how the circuit known as the Hippo pathway reprograms metabolism to promote liver cancer. These studies will enhance our understanding how metabolism regulates liver growth and identify therapeutic targets to combat liver cancer.

Funded Activity Details

Start Date: 01-01-2018

End Date: 01-01-2020

Funding Scheme: Project Grants

Funding Amount: $659,105.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cell Metabolism

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

biochemistry | cancer biology | developmental biology | liver cancer | metabolism

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