Novel Early Detection Strategy for Liver Cancer using Hepatitis B Splice Variants to Expediate Diagnosis and Improve Treatment Outcome

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1145977

Funding Status
Closed

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Funded Activity Summary

Hepatitis B virus (HBV) causes liver cancer, which is one of the only cancers that is increasing in prevalence. We have shown that smaller versions of HBV, termed splice variants, are even more strongly associated with liver cancer- people with higher levels of the splice variants were over 3 times more likely to have liver cancer. We will find out why, by thoroughly studying how the splice variants alter the virus and the host cell to promote liver cancer.

Funded Activity Details

Start Date: 01-01-2018

End Date: 01-01-2021

Funding Scheme: Project Grants

Funding Amount: $943,566.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Virology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

antiviral therapy | clinical studies | hepatitis B virus | liver cancer | splicing

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