FANC gene mutations in Acute Myeloid Leukaemia biology and treatment

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1145391

Funding Status
Closed

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Funded Activity Summary

We have found mutations in DNA repair genes in AML patients, and associated the presence of these with increased risk of developing AML. Our hypothesis is that the presence of these mutations leads to reduced efficiency of DNA repair, and increased risk of additional mutations and leukaemic transformation. Our aim is therefore to determine the changes associated with these mutations in blood cell precursors, and to investigate the potential of targeted therapies for this group of patients.

Funded Activity Details

Start Date: 01-01-2018

End Date: 01-01-2021

Funding Scheme: Project Grants

Funding Amount: $900,780.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Haematological Tumours

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

DNA repair | acute myeloid leukaemia (AML) | cancer predisposition | genetic predisposition | targeted therapy

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