Preclinical evaluation of the novel therapeutic compound APP96-110 in an ovine model of traumatic brain injury

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1145183

Funding Status
Closed

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Funded Activity Summary

Traumatic brain injury (TBI) is a significant cause of death and disability, and yet there are currently no effective treatments to improve outcome following such an insult. Our laboratory has developed a novel therapeutic compound, by identifying an endogenous neuroprotective molecule, in the amyloid precursor protein and then identifying the active site and modifying it to improve its efficacy. We will be testing this compound in our sheep model of TBI.

Funded Activity Details

Start Date: 01-01-2018

End Date: 01-01-2021

Funding Scheme: Project Grants

Funding Amount: $874,734.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Neurology and Neuromuscular Diseases

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

amyloid precursor protein | axonal injury | sheep | traumatic brain injury (TBI) | treatment

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