Modeling human Actin Related Protein 2/3 Complex subunit 1B (ARPC1B) deficiency in mice

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1144684

Funding Status
Closed

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Funded Activity Summary

The actin cytoskeleton forms the structure that not only keeps cells in their normal shape but is also essential for the movement of cells and for interaction between cells. We have recently identified the first patients with an immunodeficiency caused by a defect in a gene called ARPC1B, which plays a crucial role in the regulation of actin. Through the investigation of novel mouse models we will elucidate the pathomechanism underlying the disease of these patients.

Funded Activity Details

Start Date: 01-01-2018

End Date: 01-01-2020

Funding Scheme: Project Grants

Funding Amount: $755,005.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Immunology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

B cells | T cell memory | immunodeficiency | immunoglobulin E (IgE) | mouse models

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