Integrative systems pharmacology, neutron reflectometry and molecular dynamics approaches to unravelling the interactions between polymyxins and bacterial membranes

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1144652

Funding Status
Closed

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Funded Activity Summary

Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii are among the 6 top-priority dangerous ‘superbugs’ causing life-threatening infections worldwide. This study will employ a multi-disciplinary approach to decipher the complex interactions of polymyxins with the membranes of these three ‘superbugs’ and to discover novel antibiotics with superior efficacy. This innovative project targets the urgent unmet global medical crisis due to antibiotic resistance.

Funded Activity Details

Start Date: 01-01-2018

End Date: 01-01-2022

Funding Scheme: Project Grants

Funding Amount: $968,005.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Basic Pharmacology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

antimicrobial resistance | antimicrobial therapy | biophysics | drug discovery | systems biology

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