To Biochemically Trick P-Glycoprotein (Pgp) to Target Resistance via Lysosomal Pgp

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1144456

Funding Status
Closed

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Funded Activity Summary

We have discovered an innovative biochemical strategy whereby our novel compounds exploit and trick a part of the detoxification machinery, that is the transporter, P-glycoprotein, to specifically kill drug resistant cancer cells. Herein, we take advantage of this biochemical mechanism to design novel and safe drugs to selectively target resistant tumours.

Funded Activity Details

Start Date: 01-01-2018

End Date: 01-01-2020

Funding Scheme: Project Grants

Funding Amount: $603,848.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Receptors and Membrane Biology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

P-glycoprotein | biochemistry | lysosomes | oxidative stress | transporters

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