INFLAMMASOMES AND INTERLEUKIN-18 SIGNALLING: NOVEL BIOMARKERS AND THERAPEUTIC TARGETS FOR KIDNEY DISEASE

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1143674

Funding Status
Closed

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Funded Activity Summary

Chronic kidney disease (CKD) is a major health problem. There is no cure for CKD and current therapies merely slow its progression. Thus for many patients, dialysis or kidney transplant is an inevitable outcome. We have evidence that a protein called interleukin-18 (IL-18) is a key mediator of kidney damage in CKD. Here we will explore how IL-18 causes kidney damage and whether IL-18 may be used as a diagnostic for early detection of CKD, and a target for more effective therapies to treat CKD.

Funded Activity Details

Start Date: 01-01-2018

End Date: 01-01-2021

Funding Scheme: Project Grants

Funding Amount: $1,003,340.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cardiology (incl. Cardiovascular Diseases)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cardiovascular pharmacology | cytokines | inflammation | kidney disease | therapeutic target

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