Dissecting the pathogenic triad of enteric pathogens: Assembly, structure and function of autotransporter proteases

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1143638

Funding Status
Closed

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Funded Activity Summary

SPATEs are proteases secreted by many enteric bacteria that contribute to their pathogenic potential by damaging host tissues and evading the host immune response. We aim to study the structural basis of their assembly and biological function. The information we gain will assist the development of new diagnostics and improved therapies for enteric infections.

Funded Activity Details

Start Date: 01-01-2018

End Date: 01-01-2020

Funding Scheme: Project Grants

Funding Amount: $639,428.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

bacterial pathogenesis | enzyme mechanism | enzyme structure | microbiology | protease inhibitors

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