Targeting cancer-initiating cells with DNA methyltransferase inhibitors: single-cell analysis to decipher molecular mechanisms and improve efficacy.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1143614

Funding Status
Closed

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Funded Activity Summary

Certain cancer cells, termed cancer-initiating cells (CICs), have special properties allowing them to drive cancer growth and disease progression. These cells are particularly sensitive to low-dose treatment with drugs called DNA methyltransferase inhibitors. Using cutting-edge "single-cell" technologies this project will determine how these drugs target CICs and identify new ways to increase treatment efficacy. This work will identify new clinical opportunities for prevention of cancer relapse.

Funded Activity Details

Start Date: 01-01-2018

End Date: 01-01-2019

Funding Scheme: Project Grants

Funding Amount: $175,000.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cancer Cell Biology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

DNA methylation | cancer | epigenetics | mechanism of action | stem cells

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