Antioxidant enzymes counter reactive oxygen species from steroidogenic cytochrome P450 enzymes in the ovary to limit aneuploidy of embryos

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1143289

Funding Status
Closed

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Funded Activity Summary

Many birth defects are due to damage sustained by the eggs before ovulation. Aging allows more damage, hence the advice to have babies earlier in life. However, we believe we have identified a source of damage that happens during late development of the follicle in the weeks before ovulation. Proving this will enable us define when an egg is most at risk of damage and to devise strategies to lower the risk.

Funded Activity Details

Start Date: 01-01-2018

End Date: 01-01-2020

Funding Scheme: Project Grants

Funding Amount: $536,978.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Reproduction

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

aneuploidy | antioxidant | granulosa cells | reactive oxygen species (ROS) | steroidogenesis

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